The application of clinical knowledge to a individual patient is often filled with nuance and is hardly straightforward. In the Clinical Pearls series, we aim to use a case-based format to learn how broader concepts within hepatology can be applied in various unique settings.
A 5 month old FT baby boy presented with a five day history of abdominal distention, jaundice and was found to have significant ascites and elevated AFP. Laboratory evaluation was significant for hypoalbuminemia (albumin-1.8 g/dL), coagulopathy (INR-3.5) and elevated alpha-feto protein (23,300 ng/mL). Whole exome sequencing was non-diagnostic and he was diagnosed with cryptogenic cirrhosis. During his admission his ascites is refractory to both medical therapy and repeat paracentesis. He is listed for liver transplant. Of the following, what is the best predictor of post-transplant mortality and graft survival?
25-year-old female with hyperthyroidism who is 30 weeks pregnant initially presented with costovertebral tenderness, pelvic pain and nausea. Pain resolved after passing a kidney stone, but initial labs are concerning for abnormal liver chemistries with AST of 118 U/L, ALT of 162 U/L, alkaline phosphatase of 200 U/L, Total Bilirubin of 2.0 mg/dL and INR of 1.0. What is the next best step?
A 22-year-old male with a past medical history of anxiety and depression presents with acute psychosis after ingesting 3.5 grams of marijuana. He takes vortioxetine at home. On presentation, he was found agitated, throwing himself against walls. AST and ALT were 187 U/L and 44 U/L on admission. Five days later, AST and ALT increased to 1,402 U/L and 402 U/L. All other liver chemistry tests, hemoglobin, white blood cell count, and INR are normal. What is the most likely cause of his abnormal liver chemistry tests?
75-year-old male presents with diuretic refractory hepatic hydrothorax. No overt hepatic encephalopathy but family has noted some episodes of intermittent confusion. He is independent in his activities of daily living. MELD is less than 10. No history of congestive heart failure, chronic kidney disease or hyponatremia. What do you recommend?
A 38-year-old male presents with new-onset shortness of breath, abdominal pain, and ascites.
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