Clinical Pearls
The application of clinical knowledge to a individual patient is often filled with nuance and is hardly straightforward. In the Clinical Pearls series, we aim to use a case-based format to learn how broader concepts within hepatology can be applied in various unique settings.
Current Team
Fellow Lead
Faculty Editor
Clinical PearlsMalnutrition in the Adult with Cirrhosis
A 38-year-old male presents with new-onset shortness of breath, abdominal pain, and ascites.
Sarah UttalClinical PearlsPediatric Hepatitis B
Put your knowledge to the test in this Clinical Pearls post reviewing prevention, screening, diagnosis and treatment of HBV infections in pediatric patients!
Kanak VermaClinical PearlsIt Takes Two: Liver diseases of pregnancy
A 29-year-old previously healthy woman at 35 weeks gestation presents with bilateral leg swelling worsening over the past 5 days.
Lindsay MatthewsClinical PearlsTIP(S)ing the scales against portal hypertension
A 38-year-old male presents with new-onset shortness of breath, abdominal pain, and ascites.
Jessica MustoClinical PearlsPeeling Back The Layers of Pediatric Primary Sclerosing Cholangitis
Pathophysiology and Natural History Primary sclerosing cholangitis (PSC) is a chronic, cholestatic liver disease, thought to be immune-mediated in nature, characterized by inflammation and fibrosis…
Shruti SakhujaClinical PearlsAn Acute Severe Dilemma
A 61 year old male with a history of recently diagnosed autoimmune hepatitis presents with fatigue and generalized weakness for 1.5 weeks. He denies fevers, chills, abdominal pain or swelling, and confusion. On exam, he has scleral icterus but no ascites or asterixis. Labs are notable for a total bilirubin of 8.1, AST 1,412, ALT 1020, and INR of 1.5. What is best next step in management?
Tom CouriClinical PearlsMetallic Liver: C u Later!
A 20 year-old healthy female with no PMHx presents with lower extremity edema, abdominal distention, and a 12 pound weight-gain over 3 months. She was seen by her OB/GYN after 2 months of missed menstrual periods, and found to have elevated aminotransferases and bilirubin prompting her to present to the emergency room. full liver-work up noted an ANA screen that was positive, ferritin 176.1, hepatitis serologies normal, ASMA negative, Liver Kidney Microsomal Ab negative, normal serum alpha-1-antitrypsin.
Which gene mutation does this patient most likely have?
Abhi ShenoyClinical PearlsHepatitis C in Children
A six-month-old full term healthy female born via NSVD, attends a well child check, the pregnancy and birth were uncomplicated.
Kayla HartjesClinical PearlsHow Do I Manage Alcohol Use Disorder in Hepatology Clinic?
A 37 year-old man with a recent history of severe alcohol-associated hepatitis treated with 28 days of prednisolone presents to your outpatient clinic. How would you diagnose and manage his alcohol use disorder?
Sasha Deutsch-LinkClinical PearlsThe Real Deal Behind Alagille Syndrome
The Real Deal Behind Alagille Syndrome Background Alagille syndrome is an autosomal dominant, multisystem disorder with characteristic hepatic, cardiac, vascular, renal, skeletal, ocular, and facial…
Kanak VermaCurrent Team
Fellow Lead
Faculty Editor
Ideas?
Do you have suggestions for topics within this series? Are you a fellow interested in contributing? Please feel free to reach out via Twitter to the fellow lead or to Liver Fellow Network directly. You can also e-mail us at liverfellownetwork@gmail.com.