Evidence Corner
Welcome to Evidence Corner. Here we try to explain the data behind the clinical decisions we make through deep-diving studies that have shaped how we treat patients with liver disease. For each clinical question, we’ve chosen a single study and with our digestible slides, we try to concisely highlight the key aspects of the study.
Evidence CornerDo albumin infusions improve outcomes in hospitalized patients with cirrhosis?
Does targeting a higher albumin level via IV albumin infusions improve outcomes in hospitalized patients with cirrhosis? The ATTIRE study attempted to investigate just that. …
Erin ClevelandEvidence CornerIs terlipressin and albumin effective for HRS type-1?
Treatment options for HRS type-1 are limited and prior data for terlipressin was mixed. This RCT tried to shed further light on the efficacy of…
Lizzie AbyEvidence CornerShould patients with alcohol-associated hepatitis be treated with NAC in addition to prednisolone?
Some people treat alcohol-associated hepatitis with both NAC and prednisolone and some with just prednisolone- here is the trial that underlies this decision: https://www.nejm.org/doi/full/10.1056/nejmoa1101214
Alex VogelEvidence CornerIs liver transplantation a viable treatment for intrahepatic cholangiocarcinoma?
Can liver transplantation be an effective therapy for intrahepatic cholangiocarcinoma?
Jennifer WangEvidence CornerShould patients with clinically significant portal hypertension be on beta-blockers?
Can beta-blockade in patients with clinically significant portal hypertension prevent decompensations? The PREDESCI trial sought out to determine just that!
Lizzie AbyEvidence CornerIs Semaglutide the treatment for NASH we’ve been waiting for?
Effective treatments for NASH have been elusive. Is Semaglutide the answer people have been waiting for?
Jennifer WangEvidence CornerIs obeticholic acid effective in patients with PBC?
Is obeticholic acid effective in the treatment of patients with PBC?
Lizzie AbyEvidence CornerWhat is the best systemic therapy for unresectable HCC?
In patients with unresectable HCC, what is the best systemic therapy? https://www.nejm.org/doi/full/10.1056/NEJMoa1915745
Alex VogelEvidence CornerPredicting steroid responsiveness in patients with severe alcohol-associated hepatitis
Ever wondered why we calculate a Lille score in patients being treated for alcohol-associated hepatitis with prednisolone? This is the Evidence Corner for you!
Lizzie AbyEvidence CornerActivated CD8 T-cell Hepatitis in Children with Indeterminate Acute Liver Failure
What new condition should be considered and worked up in patients with pediatric acute liver failure of unknown origin?
Tamir DiamondIdeas?
Do you have suggestions for topics within this series? Are you a fellow interested in contributing? Please feel free to reach out via Twitter to the fellow lead or to Liver Fellow Network directly. You can also e-mail us at liverfellownetwork@gmail.com.