Brief Case Presentation A 64 year old male with history of hypertriglyceridemia presented with acute abdominal pain. Lab tests were obtained (below) and MRI abdomen…

Brief Case Presentation A 60-year-old patient with a history of heavy drinking and liver compensated cirrhosis of liver (biopsy confirmed) presented for follow-up of cirrhosis.…

Brief Case Presentation A 24 year old male with past medical history of major depressive disorder and BMI of 29.5 kg/m2 presented to his PCP…

Brief Case Presentation A 50-year-old patient with history of widely metastatic melanoma presents with fatigue, nausea, and vomiting. Scleral icterus is noted on physical exam.…

Brief Case Presentation A 17-year-old male with no significant past medical history presented with abdominal pain, diarrhea, vomiting, and elevated liver enzymes. His inflammatory markers…

Primary sclerosing cholangitis (PSC) is a primary biliary disorder characterized by progressive destruction of bile ducts. In this post we will present the most classic microscopic findings of PSC, while discussing the challenges of making this diagnosis solely based on histology.

Brief Case Presentation A 50-year-old male with a 30 pack-year smoking history and chronic obstructive pulmonary disease (COPD) status-post lung transplant presents for evaluation of…

Primary biliary cholangitis (PBC) is a chronic liver disorder caused by progressive bile duct destruction. In this post, we will present the characteristic histologic findings of PBC, as well as the key histologic differentials to keep in mind when working up a liver biopsy with portal-based inflammation.

The clinical and histologic presentation of autoimmune hepatitis (AIH) can be quite variable. Here, we present the microscopic features of AIH and discuss clinicopathologic findings that can be used to narrow the differential diagnosis, including the criteria proposed by the International Autoimmune Hepatitis Group.

In patients with chronic liver disease, liver biopsies are taken to evaluate extent and progression of disease, which helps guide therapy. Here, we discuss the microscopic features of chronic hepatitis and the two most common histologic scoring systems used to evaluate liver biopsies with chronic hepatitis.