Brief Case Presentation A 57 year old male with past medical history of alcohol use presented to the emergency department with altered mental status. The…

Brief Case Presentation A 73 year old female with past medical history of GERD, anxiety, asthma, and osteoarthritis presented with dark stools and abdominal distention.She was…

Brief Case Presentation The patient from the previous Pathology Pears post (a 50 year old with history of autoimmune hepatitis status-post liver transplant) presents for…

Brief Case Presentation A 50 year old patient with a history of autoimmune hepatitis status-post liver transplantation approximately four months ago demonstrated the laboratory results…

Brief Case Presentation A 64 year old male with history of hypertriglyceridemia presented with acute abdominal pain. Lab tests were obtained (below) and MRI abdomen…

Brief Case Presentation A 60-year-old patient with a history of heavy drinking and liver compensated cirrhosis of liver (biopsy confirmed) presented for follow-up of cirrhosis.…

Brief Case Presentation A 24 year old male with past medical history of major depressive disorder and BMI of 29.5 kg/m2 presented to his PCP…

Brief Case Presentation A 50-year-old patient with history of widely metastatic melanoma presents with fatigue, nausea, and vomiting. Scleral icterus is noted on physical exam.…

Brief Case Presentation A 17-year-old male with no significant past medical history presented with abdominal pain, diarrhea, vomiting, and elevated liver enzymes. His inflammatory markers…

Primary sclerosing cholangitis (PSC) is a primary biliary disorder characterized by progressive destruction of bile ducts. In this post we will present the most classic microscopic findings of PSC, while discussing the challenges of making this diagnosis solely based on histology.