Why is ascites always treated with a combination of furosemide and spironolactone? Why is the AST usually higher than ALT in alcoholic hepatitis? The Why? Series aims to answer your burning questions about the "dogma" of liver disease, using a combination of basic physiology, scientific evidence, and clinical experiential knowledge.
The Model for End-stage Liver Disease (or MELD) score is used to determine patient priority for liver transplantation. But have you ever wondered why? Let us review the history and the literature to better understand why this score is so meaningful!
Ursodeoxycholic acid (or UDCA, Ursodiol) is a very commonly-used medication in the hepatologist’s arsenal. But have you ever wondered what it is? Why does it work? I know I have.
Let’s try and answer some of those questions for you today!
Why, after an episode of prolonged biliary obstruction, or after severe forms of acute liver injury, does the alkaline phosphatase (ALP) rise in a delayed fashion? And why do the ALP and total bilirubin often take a while to normalize? We’ve all heard (or said) this before. Today, let’s get to the bottom of why this happens!
This one is easy peasy. Liver disease impairs albumin, so let’s give albumin replacement, right? Not so fast. There is A LOT more to albumin than meets the eye. Let’s dive in.
How many times have you prescribed diuretic therapy for a cirrhotic patient with ascites? It’s muscle memory at this point: furosemide 40mg, spironolactone 100mg. Done.…
Do you have suggestions for topics within this series? Are you a fellow interested in contributing? Please feel free to reach out via Twitter to the fellow lead or to Liver Fellow Network directly. You can also e-mail us at firstname.lastname@example.org.