https://pubmed.ncbi.nlm.nih.gov/34128254/

A 20 year-old healthy female with no PMHx presents with lower extremity edema, abdominal distention, and a 12 pound weight-gain over 3 months. She was seen by her OB/GYN after 2 months of missed menstrual periods, and found to have elevated aminotransferases and bilirubin prompting her to present to the emergency room. full liver-work up noted an ANA screen that was positive, ferritin 176.1, hepatitis serologies normal, ASMA negative, Liver Kidney Microsomal Ab negative, normal serum alpha-1-antitrypsin.

Which gene mutation does this patient most likely have?

Adam and Alex talk with Nadim Mahmud about surgical risk stratification in cirrhosis.

Have you ever wondered why we always recommend performing a diagnostic paracentesis on patients with cirrhosis when they are hospitalized? This is the study for…

Treatment of alcohol use disorder in patients with cirrhosis is essential. Here is one RCT assessing whether baclofen is a safe and effective option! https://bit.ly/3HXb9Ll

61 year old male with alcohol-related cirrhosis presents with severe ascites. He had a therapeutic paracentesis with improvement in his ascites and underwent a surveillance EGD which showed large varices that were then banded. The following day, he developed tachycardia, hypotension, and hematochezia. A nasogastric tube was placed to suction without blood return.

What is the most likely etiology of the bleed?

Primary sclerosing cholangitis (PSC) is a primary biliary disorder characterized by progressive destruction of bile ducts. In this post we will present the most classic microscopic findings of PSC, while discussing the challenges of making this diagnosis solely based on histology.

In a follow-up to an outstanding overview of NSBB therapy in liver disease, Part 2 of this series by Anahita Rabiee presents evidence in support of earlier use of NSBBs in cirrhosis. Read on!

In the first post from new LFN author Anahita Rabiee, we are gifted an authoritative review on the Whys and Hows of beta-blockade in decompensated cirrhosis! You definitely want to read this one!

In part 2 of our coagulopathy series, we take a deeper dive and learn the ways in which end-stage liver disease alters the body’s normal hemostatic mechanisms.