Some people treat alcohol-associated hepatitis with both NAC and prednisolone and some with just prednisolone- here is the trial that underlies this decision: https://www.nejm.org/doi/full/10.1056/nejmoa1101214

Adam and Alex talk with Dr. David Goldberg about policies governing organ transplantation.

Brief Case Presentation A 40-year-old female with no significant past medical history presents with fatigue and right upper quadrant pain. Physical exam is unremarkable. Results…

An 18 year old young man with chronic migraines is referred to hepatology clinic for evaluation of hepatosplenomegaly and thrombocytopenia. Neurology obtained a brain MRI showing calvarial thickening with marrow signaling but otherwise was unremarkable. His AST and ALT are 138 U/L and 150 U/L respectively, platelets 74,000/uL and hemoglobin 10.2 g/dL. At the visit, he complains of chronic leg pain that has been attributed to “growing pains”. He denies alcohol or drug use. On physical exam, liver is palpable 4 cm below costal margin at mid clavicular line with soft contour, spleen is palpable 8 cm below costal margin at mid axillary line. There is tenderness to palpation above the left femur with decrease passive range of motion secondary to pain. What is the best diagnostic test to determine etiology?